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Dan Osborn

Lecturer in Genetics

I am a developmental biologist and lecturer in animal models of human genetic disease. Before joining St George’s, I worked as a postdoctoral research associate at University College London, Institute of Child Health under the supervision of Professor Philip Beales. My work involved modelling and validating candidate cilia associated modules in zebrafish and developing high throughput methods to screen for compounds that can ameliorate cilia related disorders, such as retinal degeneration and polycystic kidney disease. I completed my PhD at King’s College London in 2008, supervised by Professor Simon Hughes (Professor of Developmental Cell Biology, Randall Division of Cell and Molecular Biophysics and Medical Research Council Centre for Developmental Neurobiology), where I used zebrafish as a tool to understand the complex genetic regulation that allows the conversion of naïve cells into functionally defined muscle fibres.

 

 

 

Evmorfia Petropoulou

Phd Student

I graduated in Molecular Biology - Genetics, from the School of Sciences, Aristotle University of Thessaloniki, Greece. I then moved to the UK where I completed an MSc in Molecular Genetics (2011) from the University of Leicester. My project title was “Copy Number Variation and Diseases- Characterisation of a structural variant on chromosome 12’’. Having been excited by the new developments in stem cell biology I wanted to gain expertise in the handling and development of stem cell models of disease - particularly induced pluripotent stem cells. Therefore I decided to undertake a Masters in Research (MRes) (with Distinction) at St. George's University of London (supervisor: Dr Y Jamshidi) where my project involved methods of obtaining induced pluripotent stem cells from hair and differentiation to cardiomyocytes (in collaboration with Dr Dimitra Dafou, and Dr Dusko Ilic, Guys Hospital, London).

My current work involves investigating the underlying genetic variants in rare cardiac arrhythmias such as Brugada syndrome.

Publications:

Coagulation Gene Expression Profiling in Infants with Necrotizing Enterocolitis. Giuliani S, Tan YW, Zheng D, Petropoulou E, Sohail A, Bradley S, Richards J, Kennea N, Jamshidi Y. J Pediatr Gastroenterol Nutr. 2016 Mar 31. [Epub ahead of print]

Whole exome sequence analysis reveals a homozygous mutation in PNPLA2 as the cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease. Muggenthaler M, Petropoulou E, Omer S, Simpson MA, Sahak H, Rice A, Raju H, Conti FJ, Bridges LR, Anderson LJ, Sharma S, Behr ER, Jamshidi Y. Int J Cardiol. 2016 May 1;210:41-4.

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Behr ER*, Savio-Galimberti E*, Barc J*, Holst AG*, Petropoulou E*, Prins BP*, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L; UK10K Consortium, Jamshidi Y. Cardiovasc Res. 2015 Jun 1;106(3):520-9.

The genetics of pro-arrhythmic adverse drug reactions. (Review) Petropoulou E, Jamshidi Y, Behr ER. Br J Clin Pharmacol. 2013 Jul 9.

 

Jaipreet Bharj

Zebrafish Technician

I graduated with a BSc in Medical Genetics from Queen Mary University of London and recently completed the Masters Human Genetics pathway at St George's. My project involved working with gene expression arrays and quantitative PCR techniques, in addition to using zebrafish as a model system for cardiovascular disease. My current position has extended this work in collaboration with Dr Yalda Jamshidi and Dr Dan Osborn.

 

 

 

 

Previous staff and students, and where they are now......

Mr William Stockdale completed his MRes in Genetics with Distinction and is now working at Oxford University on Fish Heart Regeneration.

Ms Heather Jeffery received funding from the Genetics Society to carry out a project in the Cardiogenetics lab looking at using the zebrafish model to follow up novel loci identified in genetic association studies of cardiac conduction. She has recently completed her BSc with a 1st and will shortly be starting an Interdisciplinary Bioscience PhD at Oxford University.

Bram Prins has recently taken up a position in the group of Prof Ele Zeggini at the Sanger Institute, Cambridge.

Dr Dongling Zheng - has now returned to her roots and is practising medicine.

Dr Chrysoula Dalageorgou - after finishing her PhD she has now taken a post-doc position at the Centre for Cardiology in the Young, University College London where she is working on the use of next generation sequencing techniques in cardiac arrhythmia patients, particular those with arrhythmogenic right ventricular cardiomyopathy (ARVC).

Ms Amina Paracha - having received a Genetics Society summer studentship during her BSc and then completing her final year project in the lab, winning the prize for the best student project, she went on to do a MSc in Preventitive Cardiology at Imperial College (2011). Her dissertation and project were based at St George's again where she looked at lipid data and the implications for cardiovascular disease and she finished with a Distinction.

Mr Daniel Talbott - completed his BSc in Biomedical Science in 2010 and completed his final year project in the lab investigating the role of NOS1AP in drug induced arrhythmia. The work was part of a larger study which was published in JACC in early 2012. He has recently completed an MBBS (Medicine) at St George's.

Ms Thulasi Nithiyananthan - carried out her final year BSc undergraduate project in the lab and then completed an MRes where she looked at inflammatory biomarkers in the TwinsUK study, and for which she finished with a Distinction. She has recently completed an MBBS (Medicine) at Queen Mary University of London.

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